Bacterial outer membrane vesicles as immunomodulatory agents in Helicobacter pylori infection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519518

Funding Status
Closed

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Funded Activity Summary

Chronic inflammation of the stomach is a hallmark of Helicobacter pylori infection, and is a precursor to peptic ulcer disease and cancer. Like many other bacteria, H. pylori sheds spherical blebs from its surface. These blebs bind to stomach cells in vitro and have been found in stomach biopsies of H. pylori-infected subjects. The aims of the work are to investigate the mechanisms whereby H. pylori blebs enter and disseminate within host cells, and how this may contribute to inflammation.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $306,510.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Gastritis, ulcer, cancer | Gastrointestinal infection | Helicobacter pylori | Host-pathogen interactions | Immune response | Immunity to infection | Immunity, cellular | Innate immunity | Virulence

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