The structural basis of T cell recognition in the context of lipid presentation and the CD1 isoforms

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519510

Funding Status
Closed

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Funded Activity Summary

CD1 molecules are critical in our host-defence against microbial pathogens. They survey our body for microbial lipids and then present them to our immune system for surveillance by T cell receptors. We aim to understand how a T cell receptor interacts with a CD1-lipid molecule. This interaction is crucial to the activation of our immune response and hence the elimination of the microbe. Once understood, this interaction can potentially be modified and has immunotherapeutic potential.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: Career Development Fellowships

Funding Amount: $380,558.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic radiography

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Immunotherapy of autoimmune disease eg diabetes | infectious disease | tumor immunology

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