Structural characterisation of peptide bound HLA-DQ2, HLA-DQ8, and their specific T Cell Receptors in Celiac Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519408

Funding Status
Closed

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Funded Activity Summary

Celiac disease is an inflammatory condition resulting from an inappropriate immune response to dietary gluten, present in cereals such as wheat, rye and barley. In affected individuals, ingestion of gluten can result in bloating, chronic diarrhoea, and malabsorption. At present, the only treatment is strict adherence to a gluten free diet. This project will investigate the immune response to gluten on a molecular level, aiding in the development of new treatments(e.g. non-toxic wheat varieties).

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2009

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $33,626.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Celiac Disease | T cell receptor | X-ray crystallography | antigen presentation | major histocompatibility complex

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