Function of matrix proteins important for storage and activation of TGF and TGF -induced tissue remodelling and repair

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519211

Funding Status
Closed

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Funded Activity Summary

The growth factor TGF is important for tissue development and repair, and in diseases such as pulmonary fibrosis, glomerulonephritis, liver cirrhosis, keloid formation and cancers. This project focuses on 2 important matrix proteins first discovered by Dr Gibson, LTBP-2 and ig-h3, that modulate TGF storage and TGF -induced tissue remodelling . We will use knock out mouse and cell culture models to determine the function of these proteins in tissue development and repair, and in diseases.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $690,875.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiovascular and respiratory diseases | collagen | congenital disorders | elastin (elastic fibre) | extracellular matrix | fibrosis | matrix proteins | musculoskeletal disorders | transforming growth factor | wound repair

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