Common Fragile Site Genes: Function and Contribution to Cancer Cell Biology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519125

Funding Status
Closed

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Funded Activity Summary

Common fragile sites are regions on human chromosomes that everybody has. These regions are much more sensitive to damage from agents in the environment (including the diet) than other regions in human chromosomes - so when damage does occur it is more likely to occur at these fragile sites. Many of the most sensitive fragile sites have large genes that span them. We need to understand the function of these genes to see how their disruption can contribute to cancer.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $474,597.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chromosomal fragile sites | DNA instability in cancer | WWOX, FHIT and parkin | animal models of human gene function | cancer | cell resilience | environmental DNA damage | gene function

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