The role of Nalp1 in autoimmune disease and innate immune defense as determined by murine genetic deletion.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/516783

Funding Status
Closed

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Funded Activity Summary

The innate immune system is a critical barrier against invading microorganisms, however when improperly regulated it can lead to autoimmune disease. Nalp1 is a protein that is important for innate immune recognition of anthrax infection, and is also involved in susceptibility to vitiligo and associated autoimmune diseases. This project seeks to create mice that are deficient for the gene encoding Nalp1 so as to further study the role of this protein in innate immune defense and autoimmunity.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: Early Career Fellowships

Funding Amount: $320,237.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Emergency medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmune diseases | cre induced gene knockout | innate immunity

Related Links