Generation of mouse models to study the roles of different Bcl-2 family members in the regulation of apaptosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/516776

Funding Status
Closed

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Funded Activity Summary

Programmed cell death, or apoptosis, is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. The Bcl-2 family of proteins are key regulators of apoptosis. We propose to generate several mouse models to better understand the relationships between the different members of the Bcl-2 family in an effort to control this pathway for therapeutic purposes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: Career Development Fellowships

Funding Amount: $420,872.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

knock-in | mechanisms of cell death | mouse models

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