The Role of Med12, a subunit of RNA polymerase II mediator, in haemopoiesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/516750

Funding Status
Closed

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Funded Activity Summary

In a screen of zebrafish for mutations in blood cell development, we isolated a mutant called syrah. The mutation causing the blood defect was identified in a gene called med12, which encodes a component of the RNA transcription machinery in cells. To understand how this mutation causes a reduction in blood cells, we will identify the proteins that interact with the med12 protein. Understanding the pathway involved may lead to the discovery of new causes of human congenital blood diseases.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,490.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

developmental haemopoiesis | embryonic development | genetic disease | leukopenia | molecular basis of disease | molecular biology | proteomics | transcriptional regulation | zebrafish

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