Structural studies on cell signalling via the LIF receptor and gp130

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/516730

Funding Status
Closed

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Funded Activity Summary

The cytokines play important roles in the immune system during blood cell development and inflammation, and in nerve growth, bone remodeling, reproduction and heart development. Cell responses are initiated by a cytokine bringing together on the cell surface a receptor complex made up of multiple molecules. This project will investigate the atomic structure of the cell surface macromolecular complex, and hence the underlying mechanism by which cytokine signals are initiated.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $453,943.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer | Crystallography | Cytokine Therapy | Cytokine signalling | Growth factors-receptors | Inflammation | Mutagenesis | Nerve regeneration | Receptor dimerisation

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