Understanding the role and mechanism of interaction of small heat-shock proteins in age-related disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/514615

Funding Status
Closed

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Funded Activity Summary

Protein precipitation is associated with a diversity of age-related diseases such as cataract and Alzheimer's. Within cells, a group of chaperones called the small heat-shock proteins (sHSPs) function by binding to destabilized proteins, however, common in vivo modifications can disrupt their cellular role leading to co-aggregation in a number of age-related diseases. This study will use state of the art mass spectrometry to examine the mechanism by which sHSPs interact with client proteins.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $270,827.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Analytical Biochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Ageing and vision | Biological mass spectrometry | Cataract | Protein aggregation and disease | Protein deposition disease | Protein function and structure | Small heat-shock chaperone proteins

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