Structural and Functional Studies on RNA Nuclear Retention mediated by Paraspeckles: a Novel Gene Regulation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513935

Funding Status
Closed

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Funded Activity Summary

Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2013

Funding Scheme: Early Career Fellowships

Funding Amount: $290,978.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Gene Therapy | Gene regulation | Protein-Protein and Protein-RNA Interactions | RNA binding proteins | X-ray crystallography

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