A structural and functional basis for the regulation of gene expression by nuclear retention of RNA

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513880

Funding Status
Closed

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Funded Activity Summary

The nuclear retention mechanism is a novel way used by cells to control which genes are made into proteins - a fundamental process for all diseases, particularly cancers. This project will employ cutting edge structural and proteomic techniques to determine the molecular details underpinning nuclear retention. These insights will be important for the development of new tissue-restricted gene therapy applications and drugs targeting the cancers that rely on this mechanism.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $504,097.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA binding proteins | cancer | control of gene expression | gene expression | gene structure-protein function-novel drug therapies | gene therapy | nuclear organisation | protein structure | proteomics

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