IMMUNOPHILINS IN STEROID RECEPTOR- AND TISSUE-SPECIFIC ACTIONS: IMPLICATIONS FOR TREATMENT OF STEROID-BASED DISEASE

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513869

Funding Status
Closed

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Funded Activity Summary

To convert steroid hormone signals in the cell steroid receptors rely on Hsp90 molecular chaperone machinery that is essential for receptor function and in particular 'helper' cohaperones that form part of receptor- Hsp90 complexes and fine-tune receptor responses to hormone. The present study addresses the fundamental role of the receptor helper' chaperone cyclophilin 40. Our study may have important implications for the treatment of steroid-based disease.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $480,211.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast, colon and prostate cancer | cardiovascular disease | degenerative diseases of the central nervous system | gene disruption | heat shock protein 90 | immunophilins | osteoporosis | reproductive disorders | steroid hormone action | steroid hormone rceptors

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