CSF-1 regulation of macrophage adhesion and motility and promotion of tumour invasion and metastasis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513817

Funding Status
Closed

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Funded Activity Summary

Macrophages, a type of white blood cell, infiltrate tumours and encourage tumour cells to metastasize. The mechanism involves secretion of a macrophage motility factor, CSF-1, by the tumour cells and secretion of a tumour cell motility factor by the macrophages to stimulate co-migration, invasion and metastasis. CSF-1 controls macrophage motility via the CSF-1 receptor. Dissection of receptor signalling pathways to macrophage motility will identify therapeutic targets to prevent tumour spread.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $323,453.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic radiography

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

CSF-1 signal transduction | breast cancer | cancer immunology | cell adhesion and motility | invasion and metastases | macrophage | microenvironment | tumour metastases | tyrosine kinase receptor

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