NK cells as the missing link between anti-cancer chemotherapy and CD8 T cell responses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513804

Funding Status
Closed

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Funded Activity Summary

Cytotoxic chemotherapy is the standard of care for most tumors but it rarely cures. The immune system has the capacity to destroy malignant cells but tumors usually evade immune destruction. Combination of chemo- immunotherapy may change this. DNA damage in tumor cells, caused by chemotherapy, induces expression of a set of molecules that activate Natural Killer cells. These cells can then activate anti-tumor T cells. Therapies that enhance this pathway may induce sustained anti-tumor effects.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $488,478.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic radiography

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anti-cancer immune responses | CD8 T lymphocytes | Chemotherapy and DNA damage | NKG2D ligands | Natural Killer cells | chemotherapy | combination therapy | immunotherapy | treatment resistant solid tumour

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