Functional effects of polymorphic variation of the aromatase (CYP19) gene on enzyme activity:relationship to disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513724

Funding Status
Closed

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Funded Activity Summary

After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $237,708.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

aromatase | bone loss | breast cancer | cardiovascular disease | fat metabolism | fractures | metabolism | oestrogen

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