Lyn tyrosine kinase sgnalling cascades

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/513714

Funding Status
Closed

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Funded Activity Summary

Mature red cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (Epo). Previously we had identified that the protein Lyn must be present inside primitive red blood cells for Epo to stimulate them to become mature functional cells. We will determine the role of several molecules that interact with Lyn including Cbp, Liar and LACM, towards apects of red blood cell development.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $782,525.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Erythroleukaemia | Erythropoiesis | Hematological abnormalities | Hematological malignancy | Hematopoiesis | Intracellular signal transduction | Leukaemia | Src family tyrosine kinases | Ubiquitin mediated proteolysis | protein-protein interaction

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