Regulation of immune mechanisms by pathogen cysteine proteases

Funding Activity

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Funded Activity Summary

To survive, parasites have evolved many strategies to control the human immune system. We have identified an enzyme secreted by parasites that can manipulate cells of the immune system, subsequently preventing the development of inflammatory responses. We will investigate the mechanism involved and determine whether this enzyme could be exploited for therapeutic purposes to switch off inflammation in autoimmune disease such as type-1 diabetes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $424,676.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmune diabetes | immune regulation | immune suppression | infectious disease | innate immunity | parasite disease | parasite infection | parasitology | protease | therapeutic target