Roles for MAPK-ERK1-2, -catenin-TCF and Smad3 mediated signalling pathways in TGF -induced cataract

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/512355

Funding Status
Closed

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Funded Activity Summary

Posterior capsular opacification (PCO) is a common and costly complication of cataract surgery that is caused by aberrant growth of lens cells. The TGF growth factor family causes PCO. TGF activates three signalling pathways in the lens, MAPK-ERK1-2, -catenin-TCF and Smad3; however currently we do not know which one induces PCO. This project will identify the pathway(s) that prevent TGF from causing cataracts. This is critical for the development of pharmaceuticals to prevent PCO.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $339,071.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Opthalmology And Vision Science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anterior subcapsular cataract | Cataract | Cell differentiation | Growth factor signalling | Lens pathology | Posterior capsular opacification | Secondary cataract | Transforming growth factor beta | Transgenic mice

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