Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT).

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/512245

Funding Status
Closed

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Funded Activity Summary

Congenital pseudarthrosis of the tibia or CPT is a dibilitating orthopaedic condition that affects children. Healing of a CPT is poor and, even with modern surgical techniques, amputation is a frequent outcome. As a group experienced in animal models of bone healing, we are well positioned to develop advanced genetic models of CPT in mice. With a better understanding of the underlying processes in CPT we will be able to develop treatments for this severe childhood condition.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $482,978.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone | child health | congenital limb defects | fracture repair | fractures | genetic disease | lentiviral vector | transgenic animals

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