TGFbeta isoforms differentially regulate fibrosis and inflammation in diabetic nephropathy via KLF transcription factors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/512170

Funding Status
Closed

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Funded Activity Summary

Progressive scarring and inflammation in the kidney represent the final common injury pathway for diseases that lead to kidney failure, including diabetic nephropathy. This project explores the interplay between the molecular processes that are triggered by high glucose levels in patients with diabetic nephropathy, some of which are deleterious and some potentially 'protective'. By understanding these mechanisms we will be able to prevent and more effectively treat kidney disease in diabetes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,639.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology And Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Diabetic nephropathy | Kruppel-like factors | epithelial-mesenchymal transformation | progressive kidney disease | renal failure | transforming growth factor beta

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