Antibody mutation promotes translocation: a natural cause of cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/512134

Funding Status
Closed

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Funded Activity Summary

During responses to infection, the antibody genes in responding B cells mutate at a high rate, resulting in B cells producing better antibodies. Although essential for long-lived immunity, antibody mutation involves the introduction of DNA breaks which can occasionally cause leukemia or lymphoma. We understand only poorly how DNA repair systems normally make sure that antibody mutation is benign and does not cause cancer.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $308,849.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Meiosis And Recombination

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | Immunodeficiencies | Leukaemia | Lymphoma | antibody production | gene mutation | oncogenesis | translocation

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