Molecular attributes and physiological significance of beta1L-adrenoceptors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511216

Funding Status
Closed

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Funded Activity Summary

Beta-blockers are used for the management of cardiovascular diseases including heart failure. We have discovered that one group of beta-blockers not only blocks the receptor but stimulates it. To explain this we hypothesize that human beta-adrenoceptors exist in two different 'states' , high and low. We are now determining whether 1. the low state causes progression of heart failure, 2. the molecular basis of the two states and 3. we can make new compounds to block the low state.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $754,353.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Beta-adrenoceptors | Cardiovascular disease | Cardiovascular disease prevention | Heart failure | membrane signaling | molecular pharmacology

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