The use of soluble antagonists of EphA4 in spinal cord injuries

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511212

Funding Status
Closed

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Funded Activity Summary

Permanent and limited recovery of function following spinal cord injury is a direct result of the lack of nerve regrowth through the injury. Our preliminary data suggest that antagonising the effects of EphA4, a protein involved in brain development, leads to substantial functional recovery simultaneous with nerve regrowth. In addition to designing new, more effective blockers of EphA4, we will study the signalling pathways that EphA4 activates to inhibit nerve regrowth.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $622,361.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Eph-ephrin signalling | motor recovery | movement dysfunction | nerve damage | nerve regeneration | nerve repair | neural regeneration | neurite outgrowth | spinal cord injury

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