ASSESSMENT OF ENDOPLASMIC RETICULUM STRESS AND MUTATIONS IN MUCIN OLIGOMERIZATION DOMAINS IN ULCERATIVE COLITIS

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511204

Funding Status
Closed

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Funded Activity Summary

Ulcerative colitis affects 0.2% of Australians causing chronic or recurrent health morbidity and affecting employment. In severe cases it is life threatening. Its pathogenesis remains poorly understood. We have exciting and novel preliminary data from humans and informed by our unique animal models that make us propose that the disease is caused by Endoplasmic Reticulum Stress due to misfolding of mucin. We have designed fully powered prospective clinical and lab studies to test this hypothesis.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $292,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sport and exercise nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

endoplasmic reticulum stress disease | gastrointestinal disease | genetic polymorphisms | mucins, IBD | pathogenic mechanisms | pathophysiology | ulcerative colitis

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