Cell biology of stress fractures: activation of remodelling at sites of non-union

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511187

Funding Status
Closed

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Funded Activity Summary

Stress fractures are debilitating injuries. We characterised a model of stress fractures in rat ulnae, learning that they heal by activated remodelling, that key genes are expressed in a temporal pattern, and that part of the fracture remains un-healed, similar to many clinical cases. Now, we will examine cell localisation of important genes necessary for remodelling, and test the efficacy of different growth factors to activate a healing response in the non-healed section of the fracture.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $493,817.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | bone | bone growth and fracture healing | bone resorption | fracture repair | fractures | histopathology | musculoskeletal injury, overuse | osteogenesis | tissue remodeling

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