Identification of novel therapeutic binding sites on glycine receptors by high throughput screening

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511169

Funding Status
Closed

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Funded Activity Summary

Glycine receptors mediate inhibitory neurotransmission in the nervous system. They provide fresh therapeutic targets for chronic inflammatory pain and muscle spasticity. Here we identify 5 compounds that may be appropriate as leads for discovering novel therapies for these disorders. We will use automated high throughput screening methods to discover how these drugs interact with the receptor. This will narrow down the search for the next generation of analgesic and muscle relaxant drugs.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,017.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

high throughput screening | ion channels | ligand gated ion channel function - ion channel diseases | molecular biology | neuropharmacology | pain | patch clamping

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