Role of cellular lipids in flavivirus replication

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511123

Funding Status
Closed

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Funded Activity Summary

Mosiquite bourne viruses like dengue fever and West Nile virus are responsible for many deaths each year, with little prophylatic treatments available. We want to look at how these viruses can replicate in cells and hide from our immune system. We have found that cholesterol plays a major role in efficient virus replication and is crucial for us to fight infections. Our studies have indicated that West Nile virus can alter cholesterol metabolism and concentration within our bodies.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $398,156.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

fatty acid and phospholipid metabolism | flavivirus | infectious diseases | lipid metabolism | protein trafficking | viral diseases | virus pathogenesis | virus replication

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