The mechanism of growth hormone receptor activation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511120

Funding Status
Closed

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Funded Activity Summary

Growth hormone GH excess or deficit results in considerably shortened lifespan. While cardiovascular disease is a major element in this mortality, GH status has also been linked to kidney disease and diabetic retinopathy. Importantly, GH produced locally in breast cells and prostate cells transform s these cells, creating cancers. We aim to define how GH activates its receptor, to facilitate a GH antagonist which results from understanding how GH activates its cell surface receptor.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $679,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer therapy | Cardiovascular disease | Diabetic retinopathy | Endocrine therapy | Growth hormone | Growth hormone deficiency | Hormone signalling | Obesity prevention | Tyrosine kinase receptor

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