Regulation of p75 death signalling: How neurotransmitter- and neurotrophic- signals determine cell survival

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511107

Funding Status
Closed

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Funded Activity Summary

Nerve cell survival is dependent on trophic support in the form of growth factors and synaptic input, both of which promote recovery after nerve injury. The survival pathways activated by growth factors are generally well characterised, whereas survival signals activated by synaptic activity are largely unexplored. This proposal aims to discover how synaptic activity prevents nerve cell death by looking at how synaptic activity inhibits the processes active in dying nerve cells.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $292,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | cell signalling | cell survival | nervous system development | neuronal cell death | neuronal death | neurotransmission | p75 neurotrophin receptor | phospholipids (PIP2) | potassium channels

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