Examining the role of ASIC channels in pain through the development of subtype-specific ASIC channel modulators.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/511067

Funding Status
Closed

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Funded Activity Summary

Acid sensing ion channels (ASICs) sense changes in acidity in the body. They are found throughout the body and may underlie nerve damage in stroke and some types of pain. ASICs also have many as yet unknown functions. A lack of selective tools to study ASICs is a major barrier to a complete understanding of what they do. This proposal aims to modify three animal toxins which block these receptors to make useful tools to study their function, in particular their role in sensing pain.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $617,256.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Pharmacology | ligand gated ion channel function - ion channel diseases | ligand-gated ion channels | mechanisms of pain | molecular pharmacology | neuroprotective drugs to minimise neural death after stroke | pain management | sensory neurons | structure-activity relationships

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