Innate immune factors regulate steroid-resistant airways hyperreactivity and asthma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510717

Funding Status
Closed

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Funded Activity Summary

Infection induced asthma is often difficult to manage because of lack of efficacy of steroid treatment. The innate immune system plays an important role in inflammation associated with infection. I have shown that two innate immune factors, IFN-gamma and lipopolysaccharide (LPS), induce airways hyperreactivity that is resistant to steroid therapy in a mouse model. Identification of how this pathway works may help in the treatment of infection induced steroid-resistant difficult to manage asthma.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $524,456.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway inflammation | airways hyperreactivity | asthma | asthma and respiratory innate immune system | exacerbation of asthma | innate immunity | respiratory allergy

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