Epimutations as germ-line defects in hereditary cancer syndromes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510350

Funding Status
Closed

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Funded Activity Summary

Traditionally familial cancers were thought to be caused and inherited by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that a 'chemical coat' around the MLH1 gene, causing it to be switched off, can also be inherited in some cases of bowel cancer, without any mistakes within the gene's code. We will determine if this 'coat' causes other types of cancer and if this runs in families. We also hope to find out how the coat is formed and may be reversed.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $385,925.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Disease causation | Early-onset cancers | Epigenetic inheritance | Epimutation | Familial breast cancers | Familial cancer | Familial colorectal cancers | Familial hamartomatous tumours | Hereditary cancer syndromes

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