Processes underlying establishment and maintenance of the latent HIV resevoir and potential impact of integrase inhibitors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510325

Funding Status
Closed

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Funded Activity Summary

Therapy for HIV-infected individuals is currently able to control the growth of the virus, but cannot eradicate the viral infection. This is due to a pool of CD4+ T lymphocytes which contain HIV DNA in a latent state, ready to reactivate as soon as therapy is interrupted. This project aims to better understand how this pool of latently infected CD4+ T lymphocytes is established and maintained, particularly how it is linked to the essential T cell survival signal from interleukin 7.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $318,044.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antiretroviral Drug Therapy | HIV pathogenesis | HIV-AIDS | Immunopathology | Therapy

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