Ras signalling and cholesterol efflux from late endosomes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510294

Funding Status
Closed

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Funded Activity Summary

Accumulation of cholesterol is a hallmark of early atherosclerotic lesions, known as foam cell formation. Hence the stimulation of cholesterol removal (efflux) from macrophages has great therapeutic potential. High Density Lipoproteins (HDL) and apolipoprotein A-I (apoA-I) stimulate efflux via activation of HDL-apoA-I receptors and poorly understood signalling pathways. This application is investigating the role of the Ras-MAPK signalling pathway in promoting efflux from late endosomes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $276,598.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

MAP kinases | atherosclerosis | cell signalling | cholesterol metabolism | endosomes | foam cell | lipid disorders | reverse cholesterol transport | signal transduction

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