Regulation of EGF receptor signaling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510293

Funding Status
Closed

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Funded Activity Summary

Tumour cells are often characterized by defects in signaling pathways. One of the most important signaling cascades involved in the development of cancer is the EGFR-Ras-MAPK pathway. EGFR is often overexpressed in breast cancer, leading to enhanced Ras signaling (hyperactive Ras) and cell transformation. The proposed project aims to identify the molecular mechanisms that can downregulate hyperactive Ras and will make a valuable contribution to our understanding of EGFR-Ras related cancers.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $276,598.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

EGF-EGFR signalling | RAS transformation | Ras protein | breast cancer | cancer biology | growth factors-receptors | mechanisms inhibiting cancer cell growth | plasma membrane | protein trafficking | signal transduction

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