The Leucine Rich Repeat Kinase 1 and 2 Genes are Modulators of Alternative Splicing - Implication for Neurodegeneration

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510218

Funding Status
Closed

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Funded Activity Summary

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common causes of dementia and neurodegeneration. Through positional cloning, we have identified the leucine rich repeat kinase (LRRK1) 1 gene as a modulator of alternative splicing. We have subsequently shown that its homologue, LRRK2 has a similar biological activity. We propose to study the the genetic and biochemical role of LRRK1 and LRRK2 in neurodegeneration in terms of its effect in splicing.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $583,809.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurogenetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's disease | Biochemistry and molecular biology | Degenerative diseases of the CNS | Gene regulation | Molecular basis of disease | Molecular neuroscience | Parkinson's disease | susceptibility genes

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