Role of ABCA-G transporters in neuronal cholesterol regulation and Alzheimers disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/510148

Funding Status
Closed

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Funded Activity Summary

Alzheimer's disease (AD) prevalence is rising and the contributing factors are poorly understood. Recent research shows that cholesterol regulates the production of neurotoxic amyloid-beta peptide (Abeta). We will study a class of proteins, ABC transporters, that we believe regulate neuronal cholesterol and Abeta metabolism. We will use isolated brain cells, human brain tissue and genetically engineered mice in order to define how cholesterol influences AD and identify new treatment options.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $557,582.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ATP-binding casette transporters | Alzheimer's disease | Alzheimer's disease neurodegeneration | Amyloid-beta peptide | Brain apolipoprotein E | Brain cholesterol metabolism | Neurodegenerative disease | Stress ageing and accelerated senescence

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