Role of non-classical actions of androgens in musculoskeletal physiology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509328

Funding Status
Closed

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Funded Activity Summary

Androgens (male sex hormones) are important for growth-maintenance of muscle and bone. The classical action of androgens is to bind the androgen receptor (AR) and regulate target genes. They can also act via non-classical AR mechanisms through other cellular pathways. To understand the role of non-classical actions in the musculoskeletal system we will study mice in which androgens can only act via this pathway. This knowledge is important for the treatment of osteoporosis and muscle wasting.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $703,664.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology diagnostics (incl. biosensors)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone | cell biology | hypogonadism | metabolic bone diseases | muscle wasting | muscle weakness | osteoporosis | second messenger signaling pathway | skeletal muscle | steroid hormone receptors

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