Cigaratte smoke exposure suppresses alveolar macrophage responses to lipopolysaccharide by modifying the TLR4 pathway

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509226

Funding Status
Closed

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Funded Activity Summary

Long term cigarette smoke exposure is a major risk factor for cancer, heart disease and emphysema. A less known fact about smoke exposure is that it also leaves people susceptible to respiratory infections by i) physically damaging the lung lining and ii) suppressing cells responsible for coordinating the lungs defence system. This project will identify how smoke exposure blocks the early response to infection by the immune system and discovery novel ways of restoring normal lung defences.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $506,283.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway inflammation | inflammation | macrophage activation | respiratory infection | smoking

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