Mechanisms underlying generation of Febrile Seizures in mouse models of human familial epilepsy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509224

Funding Status
Closed

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Funded Activity Summary

Febrile Seizures (FS) affect 3% of children aged 0.5 - 6 yrs and have been proposed as an indicator of severe forms of adult generalized epilepsy. Mechanisms underlying FS generation are unknown although studies of Australian families suffering from epilepsy have linked 2 genes to FS. We have generated mice expressing these 2 genes. Aims and Outcomes: to investigate events triggering FS which will provide important insights into why FS occurs in children. (NB: CIA 2 yr career interruption)

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $304,559.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Febrile Seizures | GABA A receptors | brain | epilepsy | genetic disease | ion channels | nerve excitability | sodium channel | transgenic mice

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