Inhibition of Nef-activated Src-family kinases by CHK

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509115

Funding Status
Closed

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Funded Activity Summary

HIV hijacks infected blood cells to produce its own proteins. Nef is one of these proteins and Nef alone is sufficient to cause an AIDS-like disease. Recently, we discovered that a protein called CHK can inhibit Nef. Our research will determine how CHK inhibits Nef and test the feasibility of drugs based on CHK. Such drugs would slow AIDS progression, assisting conventional therapies and patients' immune systems to combat the infection, leading to longer, healthier, more productive lives.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $514,307.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Enzyme inhibition | Enzyme-protein interactions | HIV pathogenesis | HIV treatment | HIV-AIDS | Src-family tyrosine kinases | identification of novel anti-HIV-1 target

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