Molecular mechanisms mediating experience-dependent cellular plasticity and cognitive deficits in Huntingtons disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509031

Funding Status
Closed

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Funded Activity Summary

We will use a genetic mouse model of Huntington's disease (HD), to understand how cognitive disorders (dementia) are caused, focusing on cells and molecules within the brain. We will investigate how the HD gene mutation disrupts communication between brain cells (neurons), as well as disrupting production of new cells (via adult neural stem cells). The results of this project will not only have implications for treating HD but also for other diseases involving dementia, such as Alzheimer's.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $550,387.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Huntington's disease | adult neurogenesis | cognitive disorders | dementia | gene-environment interactions | molecular neuroscience | neurodegeneration | neurodegenerative diseases | synaptic plasticity | trinucleotide repeat expansion brain disorders

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