Modulation of type 1 diabetes development by rotavirus infection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509008

Funding Status
Closed

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Funded Activity Summary

Rotavirus is the main cause of severe diarrhoea in children, and may contribute to progression to type 1 diabetes. We have now shown that rotavirus also modulates diabetes in mice, by a novel mechanism. In this project, the mechanism of this process will be elucidated and the capacity of human rotavirus to affect diabetes will be determined. This study will help determine the design of further human studies, and whether rotavirus vaccines also are possible modulators of diabetes development.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $413,775.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

rotavirus infection | rotavirus infection may be a trigger of type 1 diabetes | rotavirus presence in the pancreas during gastroenteritis | rotavirus vaccination may help prevent type 1 diabetes | type 1 diabetes | viral immunology | virus pathogenesis | virus receptors

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