The structural basis of the interaction of human relaxins with their receptors.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508995

Funding Status
Closed

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Funded Activity Summary

Relaxin is a peptide that is involved in the regulation of the birth process. It has considerable promise as an anti-fibrotic agent. Recently, another relaxin-like peptide, relaxin-3, was identified and shown to be brain-specific. It modulates the stress response and appetite. Both relaxins act upon different receptors to elicit their biological effects. To exploit their clinical potential, we will determine how these peptides selectively bind and ativate their individual receptors.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $573,807.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

CNS function | biomolecular interactions | cardiovascular-peripheral diseases | drug development | mimetics | pregnancy | relaxin | scleroderma-fibrosis | solid phase peptide synthesis | structure-activity relationships

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