Protease-activated receptor-1 (PAR-1) and regulation of Helicobacter pylori induced mucosal inflammation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508963

Funding Status
Closed

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Funded Activity Summary

Helicobacter pylori infections cause chronic gastritis which in some people results in stomach cancer or ulcers. We have identified a novel host factor, PAR-1, important for preventing this inflammation. We will use mice to identify how this molecule protects against gastritis and samples from patients to examine its importance in human disease. This will help explain why these diseases develop in some people but not others and perhaps allow identification of those at risk of developing disease.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $478,090.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial pathogenicity | Gastric adenocarcinoma | Helicobacter pylori | Host response | Inflammation | MALT lymphoma | Pathogenesis | Peptic ulcer disease

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