Understanding skeletal development: A non-proteolytic mechanism of aggrecan resorption in the growth plate

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508923

Funding Status
Closed

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Funded Activity Summary

Bone formation requires resorption of a cartilage template. We challenge the dogma that cartilage resorption is only by PROTEASES, and propose instead that GLYCOSIDASES might also be involved. Aims: Demonstrate that chondrocytes release glycosidases that are important for bone formation. Significance: New information for the design of reconstructive therapies for people with congenital and acquired limb deficiencies or inherited disorders such as arthritis and chondrodysplasias may be gained.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $563,044.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone formation | bone growth | cartilage resorption | glycosaminoglycan | growth | growth plate | hyaluronidase | lysosomal enzymes | normal growth | skeletal development

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