Role of a novel Tks5-Nck signaling pathway in cancer invasion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508912

Funding Status
Closed

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Funded Activity Summary

Invasion and metastasis are major causes of death in cancer patients. Our research has uncovered a pathway that increases the invasive potential of tumour cells in vitro. We now aim to determine if the pathway is relevant in invasion and metastasis in clinically relevant models; how a drug targeting the pathway affects invasion and; the extent to which the pathway is active in human tumours. These studies may identify a new molecular target for anti-invasive drugs.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $560,434.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Src-family tyrosine kinases | brain tumour | cancer: mechanisms of growth invasion and metastasis | cytoskeleton | extracellular matrix | invasion and metastases | melanoma | signal transduction

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