Role of PAK1 in colorectal cancer growth and metastasis regulated by gastrins

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508908

Funding Status
Closed

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Funded Activity Summary

Increased level of PAK1(a protein kinase) was associated with the progression of colorectal (large bowel) cancer (CRC). Gastrin peptides are growth factors responsible for CRC development. The objective of this project is to determine the role of PAK1 in the regulation of CRC growth and metastasis by gastrin peptides. We will use cell culture, animal models and clinical samples in the program. A successful outcome will lead to the development of new CRC therapies such as inhibitors of PAK1.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $460,070.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer metastasis | cell migration | cell proliferation | colorectal cancer | gastrointestinal tumourigenesis | growth factors-receptors | liver metastasis | p21-activated kinase 1 | regulation of tumor growth

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