Regulation of expression of the microRNA-200 family

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508089

Funding Status
Closed

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Funded Activity Summary

The majority of deaths from cancer are due to tumour metastasis. To metastasize, tumour cells must convert to a migratory form that can allow tumor cells to migrate and disseminate in the body. This process requires a genetic reprogramming of the cell. We have discovered that this genetic reprogramming is under the control of small RNA molecules called microRNAs. In this project we investigate what controls the levels of the microRNAs, to allow metastasis to occur in colon tumours.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $573,557.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Gene regulation | cancer biology | chromatin structure | colorectal cancer | epithelial transdifferentiation (EMT) | epithelial-mesenchymal transition | gene expression | metastasis | microRNA | transcription

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